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enhancerHomologSearch

Identification of putative mammalian orthologs to given enhancer

Bioconductor version: 3.24 · Package version: 1.19.2

Get ENCODE data of enhancer region via H3K4me1 peaks and search homolog regions for given sequences. The candidates of enhancer homolog regions can be filtered by distance to target TSS. The top candidates from human and mouse will be aligned to each other and then exported as multiple alignments with given enhancer.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("enhancerHomologSearch")

Details

MaintainerJianhong Ou <jou@morgridge.org>
AuthorJianhong Ou [aut, cre] (ORCID: <https://orcid.org/0000-0002-8652-2488>), Valentina Cigliola [dtc], Kenneth Poss [fnd]
LicenseGPL (>= 2)
URLhttps://jianhong.github.io/enhancerHomologSearch
Bug Reportshttps://github.com/jianhong/enhancerHomologSearch/issues
Downloads rank459
Source branchdevel
biocViewsAlignment, GeneRegulation, Sequencing, Software

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packageenhancerHomologSearch_1.19.2.tar.gz
Windows binary (x86_64)enhancerHomologSearch_1.19.2.zip
macOS binary (arm64)enhancerHomologSearch_1.19.2.tgz
macOS binary (x86_64)enhancerHomologSearch_1.19.2.tgz
Dependencies

Depends: R (>= 4.1.0), methods

Imports: BiocGenerics, Biostrings, BSgenome, BiocParallel, BiocFileCache, Seqinfo, GenomicRanges, httr, IRanges, jsonlite, motifmatchr, Matrix, MultipleAlignment, pwalign, rtracklayer, Rcpp, S4Vectors, stats, utils

LinkingTo: Rcpp

Suggests: GenomeInfoDb, knitr, rmarkdown, BSgenome.Drerio.UCSC.danRer10, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, TxDb.Hsapiens.UCSC.hg38.knownGene, org.Hs.eg.db, TxDb.Mmusculus.UCSC.mm10.knownGene, org.Mm.eg.db, MotifDb, testthat, TFBSTools