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DEXSeq

Inference of differential exon usage in RNA-Seq

Bioconductor version: 3.24 · Package version: 1.59.0

The package is focused on finding differential exon usage using RNA-seq exon counts between samples with different experimental designs. It provides functions that allows the user to make the necessary statistical tests based on a model that uses the negative binomial distribution to estimate the variance between biological replicates and generalized linear models for testing. The package also provides functions for the visualization and exploration of the results.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("DEXSeq")

Details

MaintainerHugo Gruson <hugo.gruson@embl.de>
AuthorSimon Anders [aut], Alejandro Reyes [aut, ccp] (Maintainer until 2026.), Hugo Gruson [cre]
LicenseGPL (>= 3)
Downloads rank2359
Source branchdevel
biocViewsAlternativeSplicing, DifferentialExpression, DifferentialSplicing, GeneExpression, ImmunoOncology, RNASeq, Sequencing, Software, Visualization

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packageDEXSeq_1.59.0.tar.gz
Windows binary (x86_64)DEXSeq_1.59.0.zip
macOS binary (arm64)DEXSeq_1.59.0.tgz
macOS binary (x86_64)DEXSeq_1.59.0.tgz
Dependencies

Depends: BiocParallel, Biobase, SummarizedExperiment, IRanges (>= 2.5.17), GenomicRanges (>= 1.23.7), DESeq2 (>= 1.39.6), AnnotationDbi, S4Vectors (>= 0.23.18)

Imports: BiocGenerics, biomaRt, hwriter, methods, stringr, Rsamtools, statmod, geneplotter, genefilter

Suggests: GenomeInfoDb, GenomicFeatures, txdbmaker, pasilla (>= 0.2.22), BiocStyle, knitr, rmarkdown, testthat, pasillaBamSubset, GenomicAlignments, roxygen2, glmGamPoi

Reverse dependencies

Depends On Me (3): IsoformSwitchAnalyzeR, pasilla, rnaseqDTU

Imports Me (3): diffUTR, IntEREst, pairedGSEA

Suggests Me (6): bambu, BioPlex, GenomicRanges, satuRn, stageR, subSeq