awst

Asymmetric Within-Sample Transformation

Bioconductor version: 3.23 · Package version: 1.20.0

We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples. AWST comprises two main steps: standardization and smoothing. These steps transform gene expression data to reduce the noise of the lowly expressed features, which suffer from background effects and low signal-to-noise ratio, and the influence of the highly expressed features, which may be the result of amplification bias and other experimental artifacts.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("awst")