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psichomics

Graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation

Bioconductor version: 3.24 · Package version: 1.39.1

Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("psichomics")

Details

MaintainerNuno Saraiva-Agostinho <nunodanielagostinho@gmail.com>
AuthorNuno Saraiva-Agostinho [aut, cre] (ORCID: <https://orcid.org/0000-0002-5549-105X>), Nuno Luís Barbosa-Morais [aut, led, ths] (ORCID: <https://orcid.org/0000-0002-1215-0538>), André Falcão [ths], Lina Gallego Paez [ctb], Marie Bordone [ctb], Teresa Maia [ctb], Mariana Ferreira [ctb], Ana Carolina Leote [ctb], Bernardo de Almeida [ctb]
LicenseMIT + file LICENSE
URLhttps://nuno-agostinho.github.io/psichomics/, https://github.com/nuno-agostinho/psichomics/
Bug Reportshttps://github.com/nuno-agostinho/psichomics/issues
Downloads rank624
Source branchdevel
biocViewsAlternativeSplicing, BiomedicalInformatics, DifferentialExpression, DifferentialSplicing, GUI, GeneExpression, ImmunoOncology, MultipleComparison, PrincipalComponent, RNASeq, Sequencing, Software, Survival, Transcription, Transcriptomics, Visualization

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packagepsichomics_1.39.1.tar.gz
Windows binary (x86_64)psichomics_1.39.1.zip
macOS binary (arm64)psichomics_1.39.1.tgz
macOS binary (x86_64)psichomics_1.39.1.tgz
Dependencies

Depends: R (>= 4.0), shiny (>= 1.7.0), shinyBS

Imports: AnnotationDbi, AnnotationHub, BiocFileCache, cluster, colourpicker, data.table, digest, dplyr, DT (>= 0.2), edgeR, fastICA, fastmatch, ggplot2, ggrepel, graphics, grDevices, highcharter (>= 0.5.0), htmltools, httr, jsonlite, limma, pairsD3, plyr, purrr, Rcpp (>= 0.12.14), recount, Rfast, R.utils, reshape2, shinyjs, stringr, stats, SummarizedExperiment, survival, tools, utils, XML, xtable, methods

LinkingTo: Rcpp

Suggests: testthat, knitr, parallel, devtools, rmarkdown, gplots, covr, car, rstudioapi, spelling