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deconvR

Simulation and Deconvolution of Omic Profiles

Bioconductor version: 3.24 · Package version: 1.19.1

This package provides a collection of functions designed for analyzing deconvolution of the bulk sample(s) using an atlas of reference omic signature profiles and a user-selected model. Users are given the option to create or extend a reference atlas and,also simulate the desired size of the bulk signature profile of the reference cell types.The package includes the cell-type-specific methylation atlas and, Illumina Epic B5 probe ids that can be used in deconvolution. Additionally,we included BSmeth2Probe, to make mapping WGBS data to their probe IDs easier.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("deconvR")

Details

MaintainerIrem B. Gündüz <irembgunduz@gmail.com>
AuthorIrem B. Gündüz [aut, cre] (ORCID: <https://orcid.org/0000-0003-2641-0916>), Veronika Ebenal [aut] (ORCID: <https://orcid.org/0000-0001-7976-3964>), Altuna Akalin [aut] (ORCID: <https://orcid.org/0000-0002-0468-0117>)
LicenseArtistic-2.0
URLhttps://github.com/BIMSBbioinfo/deconvR
Bug Reportshttps://support.bioconductor.org/t/deconvR
Downloads rank485
Source branchdevel
biocViewsDNAMethylation, GeneExpression, RNASeq, Regression, SingleCell, Software, StatisticalMethod, Transcriptomics

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packagedeconvR_1.19.1.tar.gz
Windows binary (x86_64)deconvR_1.19.1.zip
macOS binary (arm64)deconvR_1.19.1.tgz
macOS binary (x86_64)deconvR_1.19.1.tgz
Dependencies

Depends: R (>= 4.1), data.table (>= 1.14.0)

Imports: S4Vectors (>= 0.30.0), methylKit (>= 1.18.0), IRanges (>= 2.26.0), GenomicRanges (>= 1.44.0), BiocGenerics (>= 0.38.0), stats, methods, foreach (>= 1.5.1), magrittr (>= 2.0.1), matrixStats (>= 0.61.0), e1071 (>= 1.7.9), quadprog (>= 1.5.8), nnls (>= 1.4), rsq (>= 2.2), MASS, utils, dplyr (>= 1.0.7), tidyr (>= 1.1.3), assertthat, minfi

Suggests: testthat (>= 3.0.0), roxygen2 (>= 7.1.2), doParallel (>= 1.0.16), parallel, knitr (>= 1.34), BiocStyle (>= 2.20.2), reshape2 (>= 1.4.4), ggplot2 (>= 3.3.5), rmarkdown, devtools (>= 2.4.2), sessioninfo (>= 1.1.1), covr, RefManageR