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CATALYST

Cytometry dATa anALYSis Tools

Bioconductor version: 3.24 · Package version: 1.37.0

CATALYST provides tools for preprocessing of and differential discovery in cytometry data such as FACS, CyTOF, and IMC. Preprocessing includes i) normalization using bead standards, ii) single-cell deconvolution, and iii) bead-based compensation. For differential discovery, the package provides a number of convenient functions for data processing (e.g., clustering, dimension reduction), as well as a suite of visualizations for exploratory data analysis and exploration of results from differential abundance (DA) and state (DS) analysis in order to identify differences in composition and expression profiles at the subpopulation-level, respectively.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("CATALYST")

Details

MaintainerHelena L. Crowell <helena@crowell.eu>
AuthorHelena L. Crowell [aut, cre] (ORCID: <https://orcid.org/0000-0002-4801-1767>), Vito R.T. Zanotelli [aut] (ORCID: <https://orcid.org/0000-0001-7268-311X>), Stéphane Chevrier [aut, dtc] (ORCID: <https://orcid.org/0000-0002-9216-7910>), Mark D. Robinson [aut, fnd] (ORCID: <https://orcid.org/0000-0002-3048-5518>), Bernd Bodenmiller [fnd] (ORCID: <https://orcid.org/0000-0002-6325-7861>)
LicenseGPL (>=2)
URLhttps://github.com/HelenaLC/CATALYST
Bug Reportshttps://github.com/HelenaLC/CATALYST/issues
Downloads rank944
Source branchdevel
biocViewsClustering, DataImport, DifferentialExpression, ExperimentalDesign, FlowCytometry, ImmunoOncology, MassSpectrometry, Normalization, Preprocessing, SingleCell, Software, StatisticalMethod, Visualization

Documentation

Download

Follow the installation instructions to use this package in your R session.

Source packageCATALYST_1.37.0.tar.gz
Windows binary (x86_64)CATALYST_1.37.0.zip
macOS binary (arm64)CATALYST_1.37.0.tgz
macOS binary (x86_64)CATALYST_1.37.0.tgz
Dependencies

Depends: R (>= 4.5), SingleCellExperiment

Imports: circlize, ComplexHeatmap, ConsensusClusterPlus, cowplot, dplyr, drc, flowCore, FlowSOM, ggplot2, ggrepel, ggridges, graphics, grDevices, grid, gridExtra, Matrix, matrixStats, methods, nnls, RColorBrewer, reshape2, Rtsne, SummarizedExperiment, S4Vectors, scales, scater, stats

Suggests: BiocStyle, diffcyt, flowWorkspace, ggcyto, knitr, openCyto, rmarkdown, testthat, uwot

Reverse dependencies

Depends On Me (2): cytofWorkflow, spillR

Imports Me (2): CySA, cytofQC

Suggests Me (3): diffcyt, imcRtools, treekoR