Bliss {synergyfinder} | R Documentation |
Bliss
calculates the synergy score matrix for a block of
drug combination by using a druginteraction reference model introduced by
C. I. Bliss in 1939.
Bliss(response.mat)
response.mat |
A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth. |
This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The expected effect of two drugs acting independently".
A matrix for synergy score calculated via reference model introduced by C. I. Bliss.
Liye He liye.he@helsinki.fi
Shuyu Zheng shuyu.zheng@helsinki.fi
Yadav B, Wennerberg K, Aittokallio T, Tang J. (2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Comput Struct Biotechnol J, 13:504– 513.
Bliss, C. I. (1939). The toxicity of poisons applied jointly. Annals of Applied Biology, 26(3):585–615.
data("mathews_screening_data") data <- ReshapeData(mathews_screening_data) Bliss.score <- Bliss(data$dose.response.mats[[1]])