detectionPnegNormGS {sesame}R Documentation

Detection P-value emulating Genome Studio

Description

The function takes a SigSet as input, computes detection p-value using negative control probes parametrized in a normal distribution a la Genome Studio and returns a new SigSet with an updated pval slot.

Usage

detectionPnegNormGS(sset)

Arguments

sset

a SigSet

Details

P-value is calculated using negative control probes as the estimate of background where Grn channel and Red channel are merged. But when estimating p-value the Red and Grn are summed (non-ideal).

Value

detection p-value

Examples

sset <- makeExampleSeSAMeDataSet()
sset <- detectionPnegNormGS(sset)


[Package sesame version 1.2.0 Index]