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TCGAbiolinksGUI: a graphical user interface (GUI) for integrative analysis of TCGA data.

Description of the menus

Step 1 Data
> Get GDC Data Download GDC data (molecular, mutation, clinical, subtype information) that will be used in the analysis steps.
Step 2 Analysis
> Clinical analysis Perform a survival analysis.
> Epigenetic analysis Perform differentially methylated regions (DMR) analysis.The result can be seen through a volcano plot, a heatmap plot.
> Transcriptomic analysis Perform differential expression analysis (DEA). The result can be viewed through a volcano plot and a heatmap plot. Also, for the genes that were identified as upregulated or downregulated an enrichment analysis can be done.
> Genomic analysis Visualize mutation status through a oncoprint using a Mutation Annotation Format (MAF) file.
Step 3Integrative analysis
> Starburst plot Integrate the epigenetic analysis and transcriptomic analysis results using a starburstplot (correlates the DNA methylation level and nearest gene expression level)
> ELMER Identify candidate regulatory elements in the non-coding regions of the genome associated with cancer using the R/Bioconductor ELMER pacakge.