HSA {synergyfinder} | R Documentation |
A function to calculate HSA synergy score based on HSA model
HSA(response.mat, correction = TRUE, Emin = NA, Emax = NA, nan.handle = c("LL4", "L4"))
response.mat |
a dose-response matrix with concentrations as row names and column names |
correction |
a parameter to specify if baseline correction is used or not. Defaults to TRUE. |
Emin |
the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. It is used only when correction is required. |
Emax |
the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. It is used only when correction is required. |
nan.handle |
a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs. |
A matrix of HSA synergy scores for all the dose pairs for a drug combination. For a does pair with at least one zero concentration, 0 is used as the synergy score.
Liye He liye.he@helsinki.fi
data("mathews_screening_data") data <- ReshapeData(mathews_screening_data) delta.score <- HSA(data$dose.response.mats[[1]])