regulation.scores {joda} | R Documentation |
Regulation scores reflect the actual regulatory influence of the regulators on the genes. For each regulator, these are probabilities of differential expression averaged over all perturbation experiments that affect the regulator.
regulation.scores(probs, model, verbose)
probs |
A matrix of probabilities of differential expression of the genes
(rows) under perturbations of regulators (columns). Obtained with the |
model |
A pathway |
verbose |
When TRUE, the execution prints informative messages |
A matrix with columns for the regulators, rows for the genes, and entries giving the regulation scores.
Ewa Szczurek
http://joda.molgen.mpg.de
differential.probs
, deregulation.scores
data(damage) # Get the probabilities of differential expression # for the knockouts of ATM, RelA and p53 in healthy cells probs.healthy= differential.probs(data.healthy, beliefs.healthy) #Get the regulation scores for ATM, RelA and for p53 regulation.healthy= regulation.scores(probs.healthy, model.healthy, TRUE)