ppi_enrichment {STRINGdb}R Documentation

ppi_enrichment

Description

Computes the enrichment in protein-protein interactions.

Usage

ppi_enrichment(hitList, ppi_network)

Arguments

hitList

sorted list of proteins (from the most significant to the least significant)

ppi_network

an igraph object containing the graph of the protein-protein interaction's network.

Value

enrichment

pvalue that describes the probability to get such a number of interactions by chance

lambda

expected number of interactions

Author(s)

Andrea Franceschini

References

Pradines JR, Farutin V, Rowley S, Dancik V. Analyzing protein lists with large networks: edge-count probabilities in random graphs with given expected degrees. J. Comput. Biol. 2005;12:113-128. Franceschini, A et al. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. In:Nucleic Acids Res. 2013 Jan;41(Database issue)


[Package STRINGdb version 1.20.0 Index]