1 Abstract

Discovering disease-disease simialrties can be useful for us to inferring the mechanisms of complex diseases. Disease similarity has become the important basis in disease-related molecular function research. There have been a number of methods proposed for measuring disease similarity in recent years. But there are lacks of tools or web servers for the computation of these methods. We present an R package dSimer which provides computation of nine methods for measuring disease-disease similarity, including a standard cosine similarity measure and eight function-based methods. The disease similarity matrix obtained from these nine methods can be visualized through heatmap and network. Biological data widely used in disease-disease associations study are also provided by dSimer.

2 Introduction

The quantification of similarity among diseases has drawn more and more attention in modern biology and medicine. Understanding similarity among diseases can not only help us gain deeper insights into complex diseases, but also lead to improvements in disease diagnosis, drug repurposing and new drug development. Due to the growing body of high-throughput biological data such as genomic and proteomic data, a number of methods have been proposed for the computation of similarity among diseases during the past decade.

Here we present dSimer for the calculation of nine disease similarity methods, including one standard cosine similarity method [1, 2] and eight function-based methods which compare disease-related gene set for calculating [3]. Besides, we also implemented methods for the visualization of disease similarity matrix.

To start with dSimer package, type following codes below:

library(dSimer)
help("dSimer")

3 The standard cosine similarity method

The cosine similarity method is a widely used standard measure in disease association analyses [1, 2]. First it constructs feature vectors for diseases from literature or by using other biological data. Then it calculate the cosine of the angle between normalized vector pairs as the similarity scores between diseases. We implemented function CosineDFV for this method:

data(d2s_hsdn) #get disease-symptom associations for constructing feature vectors
ds <- sample(unique(d2s_hsdn[,2]), 5) #get disease names sample
simmat <- CosineDFV(ds, ds, d2s_hsdn)
simmat

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Lupus Nephritis
## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1.0000000000
## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                0.0007900049
## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             0.0396889804
## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome    0.0000000000
## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Uterine Cervical Diseases
## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.0007900049
## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1.0000000000
## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0.0022674518
## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome              0.0000000000
## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                0.0049299949
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Tuberculosis
## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        0.039688980
## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              0.002267452
## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           1.000000000
## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome  0.342110379
## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.010256138
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome
## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    0.0000000
## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          0.0000000
## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       0.3421104
## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1.0000000
## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                0.0000000
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Mandibular Diseases
## Lupus Nephritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               0.001865832
## Uterine Cervical Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     0.004929995
## Tuberculosis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  0.010256138
## Silo Fillers Disease\t1\t1.3147291510963324\nCough\tAnti-Glomerular Basement Membrane Disease\t3\t3.944187453288997\nCough\tHistiocytosis, Langerhans-Cell\t10\t13.147291510963324\nCough\tIdiopathic Pulmonary Fibrosis\t29\t38.12714538179364\nCough\tPneumoconiosis\t19\t24.979853870830315\nCough\tAsbestosis\t9\t11.83256235986699\nCough\tByssinosis\t4\t5.2589166043853295\nCough\tSilicosis\t8\t10.517833208770659\nCough\tSarcoidosis, Pulmonary\t20\t26.29458302192665\nCough\tWegener Granulomatosis\t9\t11.83256235986699\nCough\tLung Diseases, Obstructive\t93\t122.26981105195891\nCough\tPulmonary Disease, Chronic Obstructive\t90\t118.3256235986699\nCough\tLung Injury\t1\t1.3147291510963324\nCough\tMeconium Aspiration Syndrome\t1\t1.3147291510963324\nCough\tBronchopulmonary Dysplasia\t2\t2.6294583021926647\nCough\tPneumonia\t95\t124.89926935415157\nCough\tPleuropneumonia\t1\t1.3147291510963324\nCough\tPneumonia, Aspiration\t35\t46.01552028837163\nCough\tPneumonia, Lipid\t5\t6.573645755481662\nCough\tPulmonary Alveolar Proteinosis\t7\t9.203104057674327\nCough\tPulmonary Atelectasis\t20\t26.29458302192665\nCough\tMiddle Lobe Syndrome\t5\t6.573645755481662\nCough\tPulmonary Edema\t21\t27.60931217302298\nCough\tPulmonary Embolism\t22\t28.92404132411931\nCough\tPulmonary Emphysema\t31\t40.756603683986306\nCough\tLung, Hyperlucent\t1\t1.3147291510963324\nCough\tPulmonary Eosinophilia\t30\t39.44187453288997\nCough\tPulmonary Fibrosis\t27\t35.49768707960097\nCough\tPulmonary Veno-Occlusive Disease\t1\t1.3147291510963324\nCough\tRespiratory Distress Syndrome, Adult\t8\t10.517833208770659\nCough\tRespiratory Distress Syndrome, Newborn\t6\t7.888374906577994\nCough\tScimitar Syndrome\t2\t2.6294583021926647\nCough\tNose Diseases\t6\t7.888374906577994\nCough\tEpistaxis\t2\t2.6294583021926647\nCough\tNasal Obstruction\t4\t5.2589166043853295\nCough\tNasal Polyps\t1\t1.3147291510963324\nCough\tParanasal Sinus Diseases\t3\t3.944187453288997\nCough\tSinusitis\t46\t60.47754095043129\nCough\tMaxillary Sinusitis\t2\t2.6294583021926647\nCough\tRhinitis\t54\t70.99537415920194\nCough\tRhinitis, Allergic, Perennial\t18\t23.66512471973398\nCough\tRhinitis, Allergic, Seasonal\t24\t31.553499626311975\nCough\tRhinitis, Atrophic\t1\t1.3147291510963324\nCough\tRhinitis, Vasomotor\t1\t1.3147291510963324\nCough\tPleural Diseases\t11\t14.462020662059656\nCough\tChylothorax\t1\t1.3147291510963324\nCough\tHydrothorax\t2\t2.6294583021926647\nCough\tPleural Effusion\t21\t27.60931217302298\nCough\tPleurisy\t9\t11.83256235986699\nCough\tPneumothorax\t23\t30.238770475215645\nCough\tRespiration Disorders\t72\t94.66049887893593\nCough\tAltitude Sickness\t5\t6.573645755481662\nCough\tApnea\t9\t11.83256235986699\nCough\tSleep Apnea Syndromes\t13\t17.09147896425232\nCough\tSleep Apnea, Central\t1\t1.3147291510963324\nCough\tSleep Apnea, Obstructive\t5\t6.573645755481662\nCough\tCough\t4598\t6045.124636740937\nCough\tDyspnea\t155\t203.78301841993152\nCough\tDyspnea, Paroxysmal\t2\t2.6294583021926647\nCough\tHyperventilation\t10\t13.147291510963324\nCough\tMouth Breathing\t2\t2.6294583021926647\nCough\tRespiratory Aspiration\t13\t17.09147896425232\nCough\tRespiratory Insufficiency\t60\t78.88374906577994\nCough\tAirway Obstruction\t70\t92.03104057674327\nCough\tHypoventilation\t2\t2.6294583021926647\nCough\tRespiratory Paralysis\t4\t5.2589166043853295\nCough\tRespiratory Hypersensitivity\t52\t68.36591585700928\nCough\tRespiratory System Abnormalities\t1\t1.3147291510963324\nCough\tBronchopulmonary Sequestration\t4\t5.2589166043853295\nCough\tRespiratory Tract Fistula\t3\t3.944187453288997\nCough\tEpiglottitis\t4\t5.2589166043853295\nCough\tTracheitis\t10\t13.147291510963324\nCough\tThoracic Diseases\t7\t9.203104057674327\nCough\tMediastinal Diseases\t8\t10.517833208770659\nCough\tMediastinal Emphysema\t20\t26.29458302192665\nCough\tMediastinitis\t1\t1.3147291510963324\nCough\tTracheal Diseases\t52\t68.36591585700928\nCough\tTracheal Stenosis\t14\t18.406208115348655\nCough\tEar Diseases\t1\t1.3147291510963324\nCough\tEarache\t2\t2.6294583021926647\nCough\tHearing Loss, Bilateral\t1\t1.3147291510963324\nCough\tHearing Loss, Functional\t1\t1.3147291510963324\nCough\tLabyrinth Diseases\t1\t1.3147291510963324\nCough\tVertigo\t1\t1.3147291510963324\nCough\tOtitis\t1\t1.3147291510963324\nCough\tOtitis Externa\t1\t1.3147291510963324\nCough\tOtitis Media\t5\t6.573645755481662\nCough\tOtitis Media with Effusion\t1\t1.3147291510963324\nCough\tMultiple Sclerosis\t6\t7.888374906577994\nCough\tMyasthenia Gravis\t1\t1.3147291510963324\nCough\tGuillain-Barre Syndrome\t2\t2.6294583021926647\nCough\tHereditary Sensory and Autonomic Neuropathies\t3\t3.944187453288997\nCough\tGiant Cell Arteritis\t26\t34.18295792850464\nCough\tAutonomic Nervous System Diseases\t4\t5.2589166043853295\nCough\tAdie Syndrome\t4\t5.2589166043853295\nCough\tHypotension, Orthostatic\t1\t1.3147291510963324\nCough\tSyncope, Vasovagal\t2\t2.6294583021926647\nCough\tCentral Nervous System Diseases\t1\t1.3147291510963324\nCough\tBrain Diseases\t3\t3.944187453288997\nCough\tParkinson Disease\t11\t14.462020662059656\nCough\tParkinson Disease, Postencephalitic\t1\t1.3147291510963324\nCough\tSupranuclear Palsy, Progressive\t1\t1.3147291510963324\nCough\tTourette Syndrome\t4\t5.2589166043853295\nCough\tCerebral Palsy\t4\t5.2589166043853295\nCough\tBrain Death\t1\t1.3147291510963324\nCough\tBrain Diseases, Metabolic, Inborn\t1\t1.3147291510963324\nCough\tGlycogen Storage Disease Type II\t2\t2.6294583021926647\nCough\tNiemann-Pick Disease, Type B\t1\t1.3147291510963324\nCough\tBrain Edema\t1\t1.3147291510963324\nCough\tBrain Injuries\t2\t2.6294583021926647\nCough\tPneumocephalus\t3\t3.944187453288997\nCough\tCerebellar Diseases\t1\t1.3147291510963324\nCough\tCerebellar Ataxia\t1\t1.3147291510963324\nCough\tAtaxia Telangiectasia\t1\t1.3147291510963324\nCough\tCerebrovascular Disorders\t7\t9.203104057674327\nCough\tBrain Ischemia\t3\t3.944187453288997\nCough\tBrain Infarction\t1\t1.3147291510963324\nCough\tBrain Stem Infarctions\t1\t1.3147291510963324\nCough\tLateral Medullary Syndrome\t1\t1.3147291510963324\nCough\tCerebral Infarction\t18\t23.66512471973398\nCough\tInfarction, Middle Cerebral Artery\t1\t1.3147291510963324\nCough\tIschemic Attack, Transient\t1\t1.3147291510963324\nCough\tCarotid Artery Diseases\t4\t5.2589166043853295\nCough\tCarotid Artery Thrombosis\t1\t1.3147291510963324\nCough\tCarotid Stenosis\t1\t1.3147291510963324\nCough\tVertebral Artery Dissection\t1\t1.3147291510963324\nCough\tIntracranial Aneurysm\t2\t2.6294583021926647\nCough\tIntracranial Arteriosclerosis\t1\t1.3147291510963324\nCough\tIntracranial Arteriovenous Malformations\t1\t1.3147291510963324\nCough\tIntracranial Embolism and Thrombosis\t2\t2.6294583021926647\nCough\tIntracranial Embolism\t3\t3.944187453288997\nCough\tCerebral Hemorrhage\t4\t5.2589166043853295\nCough\tHematoma, Epidural, Cranial\t2\t2.6294583021926647\nCough\tHematoma, Subdural\t2\t2.6294583021926647\nCough\tSubarachnoid Hemorrhage\t2\t2.6294583021926647\nCough\tStroke\t15\t19.720937266444984\nCough\tVascular Headaches\t1\t1.3147291510963324\nCough\tDementia\t1\t1.3147291510963324\nCough\tCreutzfeldt-Jakob Syndrome\t2\t2.6294583021926647\nCough\tMeningoencephalitis\t2\t2.6294583021926647\nCough\tEpilepsy\t11\t14.462020662059656\nCough\tEpilepsies, Partial\t3\t3.944187453288997\nCough\tEpilepsy, Temporal Lobe\t3\t3.944187453288997\nCough\tSeizures\t10\t13.147291510963324\nCough\tHeadache Disorders\t1\t1.3147291510963324\nCough\tHeadache Disorders, Primary\t2\t2.6294583021926647\nCough\tMigraine Disorders\t4\t5.2589166043853295\nCough\tMigraine without Aura\t1\t1.3147291510963324\nCough\tTension-Type Headache\t1\t1.3147291510963324\nCough\tCluster Headache\t2\t2.6294583021926647\nCough\tParoxysmal Hemicrania\t1\t1.3147291510963324\nCough\tHydrocephalus\t4\t5.2589166043853295\nCough\tHypoxia, Brain\t2\t2.6294583021926647\nCough\tIntracranial Hypertension\t1\t1.3147291510963324\nCough\tHypertensive Encephalopathy\t1\t1.3147291510963324\nCough\tPseudotumor Cerebri\t2\t2.6294583021926647\nCough\tIntracranial Hypotension\t2\t2.6294583021926647\nCough\tSubdural Effusion\t1\t1.3147291510963324\nCough\tMovement Disorders\t2\t2.6294583021926647\nCough\tDyskinesias\t1\t1.3147291510963324\nCough\tTorticollis\t2\t2.6294583021926647\nCough\tEssential Tremor\t1\t1.3147291510963324\nCough\tTic Disorders\t8\t10.517833208770659\nCough\tSpinal Cord Diseases\t2\t2.6294583021926647\nCough\tAmyotrophic Lateral Sclerosis\t18\t23.66512471973398\nCough\tMuscular Atrophy, Spinal\t1\t1.3147291510963324\nCough\tSpinal Muscular Atrophies of Childhood\t3\t3.944187453288997\nCough\tSpinal Cord Injuries\t18\t23.66512471973398\nCough\tSyringomyelia\t5\t6.573645755481662\nCough\tCranial Nerve Diseases\t2\t2.6294583021926647\nCough\tHypoglossal Nerve Diseases\t1\t1.3147291510963324\nCough\tNystagmus, Pathologic\t2\t2.6294583021926647\nCough\tOptic Nerve Diseases\t2\t2.6294583021926647\nCough\tOptic Neuritis\t1\t1.3147291510963324\nCough\tTrigeminal Neuralgia\t1\t1.3147291510963324\nCough\tVagus Nerve Diseases\t6\t7.888374906577994\nCough\tHereditary Sensory and Motor Neuropathy\t3\t3.944187453288997\nCough\tArnold-Chiari Malformation\t14\t18.406208115348655\nCough\tMeningocele\t1\t1.3147291510963324\nCough\tMotor Neuron Disease\t3\t3.944187453288997\nCough\tBulbar Palsy, Progressive\t2\t2.6294583021926647\nCough\tDecerebrate State\t8\t10.517833208770659\nCough\tDystonia\t1\t1.3147291510963324\nCough\tMyoclonus\t1\t1.3147291510963324\nCough\tPsychomotor Agitation\t1\t1.3147291510963324\nCough\tTics\t1\t1.3147291510963324\nCough\tLanguage Disorders\t1\t1.3147291510963324\nCough\tSpeech Disorders\t1\t1.3147291510963324\nCough\tMutism\t1\t1.3147291510963324\nCough\tConfusion\t2\t2.6294583021926647\nCough\tDelirium\t1\t1.3147291510963324\nCough\tConsciousness Disorders\t6\t7.888374906577994\nCough\tUnconsciousness\t2\t2.6294583021926647\nCough\tComa\t3\t3.944187453288997\nCough\tSyncope\t110\t144.62020662059655\nCough\tMemory Disorders\t1\t1.3147291510963324\nCough\tAmnesia\t1\t1.3147291510963324\nCough\tMental Retardation\t1\t1.3147291510963324\nCough\tDown Syndrome\t3\t3.944187453288997\nCough\tHallucinations\t2\t2.6294583021926647\nCough\tNeurogenic Inflammation\t1\t1.3147291510963324\nCough\tMuscular Atrophy\t1\t1.3147291510963324\nCough\tSpasm\t1\t1.3147291510963324\nCough\tPain\t30\t39.44187453288997\nCough\tBack Pain\t4\t5.2589166043853295\nCough\tHeadache\t43\t56.53335349714229\nCough\tNeck Pain\t1\t1.3147291510963324\nCough\tSciatica\t1\t1.3147291510963324\nCough\tParalysis\t2\t2.6294583021926647\nCough\tHemiplegia\t2\t2.6294583021926647\nCough\tParaplegia\t4\t5.2589166043853295\nCough\tQuadriplegia\t14\t18.406208115348655\nCough\tTonic Pupil\t2\t2.6294583021926647\nCough\tSensation Disorders\t1\t1.3147291510963324\nCough\tDizziness\t3\t3.944187453288997\nCough\tOlfaction Disorders\t1\t1.3147291510963324\nCough\tParesthesia\t1\t1.3147291510963324\nCough\tDysgeusia\t1\t1.3147291510963324\nCough\tVision Disorders\t1\t1.3147291510963324\nCough\tBlindness\t4\t5.2589166043853295\nCough\tNeuromuscular Diseases\t36\t47.33024943946796\nCough\tPeripheral Nervous System Diseases\t4\t5.2589166043853295\nCough\tDiabetic Neuropathies\t7\t9.203104057674327\nCough\tMononeuropathies\t1\t1.3147291510963324\nCough\tNerve Compression Syndromes\t4\t5.2589166043853295\nCough\tThoracic Outlet Syndrome\t1\t1.3147291510963324\nCough\tNeuritis\t1\t1.3147291510963324\nCough\tPOEMS Syndrome\t1\t1.3147291510963324\nCough\tNeurotoxicity Syndromes\t1\t1.3147291510963324\nCough\tArsenic Poisoning\t2\t2.6294583021926647\nCough\tSleep Disorders\t7\t9.203104057674327\nCough\tSleep Initiation and Maintenance Disorders\t4\t5.2589166043853295\nCough\tCraniocerebral Trauma\t4\t5.2589166043853295\nCough\tShaken Baby Syndrome\t1\t1.3147291510963324\nCough\tSkull Fractures\t1\t1.3147291510963324\nCough\tConjunctival Diseases\t1\t1.3147291510963324\nCough\tConjunctivitis\t4\t5.2589166043853295\nCough\tConjunctivitis, Allergic\t1\t1.3147291510963324\nCough\tKeratitis\t1\t1.3147291510963324\nCough\tChoroid Hemorrhage\t1\t1.3147291510963324\nCough\tRetinal Hemorrhage\t3\t3.944187453288997\nCough\tEyelid Diseases\t1\t1.3147291510963324\nCough\tBlepharoptosis\t1\t1.3147291510963324\nCough\tLacrimal Apparatus Diseases\t2\t2.6294583021926647\nCough\tGlaucoma\t3\t3.944187453288997\nCough\tGlaucoma, Open-Angle\t1\t1.3147291510963324\nCough\tOcular Hypotension\t1\t1.3147291510963324\nCough\tOrbital Diseases\t3\t3.944187453288997\nCough\tExophthalmos\t2\t2.6294583021926647\nCough\tMyopia\t1\t1.3147291510963324\nCough\tDiabetic Retinopathy\t1\t1.3147291510963324\nCough\tIris Diseases\t1\t1.3147291510963324\nCough\tGenital Diseases, Male\t1\t1.3147291510963324\nCough\tHemospermia\t1\t1.3147291510963324\nCough\tProstatic Hyperplasia\t2\t2.6294583021926647\nCough\tUrologic Diseases\t1\t1.3147291510963324\nCough\tKidney Diseases\t2\t2.6294583021926647\nCough\tDiabetes Insipidus\t1\t1.3147291510963324\nCough\tDiabetes Insipidus, Neurogenic\t1\t1.3147291510963324\nCough\tDiabetic Nephropathies\t1\t1.3147291510963324\nCough\tGlomerulonephritis\t2\t2.6294583021926647\nCough\tGlomerulonephritis, Membranoproliferative\t1\t1.3147291510963324\nCough\tNephrotic Syndrome\t2\t2.6294583021926647\nCough\tRenal Artery Obstruction\t1\t1.3147291510963324\nCough\tRenal Insufficiency\t1\t1.3147291510963324\nCough\tAcute Kidney Injury\t4\t5.2589166043853295\nCough\tKidney Failure, Chronic\t6\t7.888374906577994\nCough\tUrethral Diseases\t1\t1.3147291510963324\nCough\tUrinary Bladder Neck Obstruction\t1\t1.3147291510963324\nCough\tUrinary Bladder, Overactive\t2\t2.6294583021926647\nCough\tUrination Disorders\t6\t7.888374906577994\nCough\tHematuria\t1\t1.3147291510963324\nCough\tOliguria\t1\t1.3147291510963324\nCough\tAlbuminuria\t2\t2.6294583021926647\nCough\tUrinary Incontinence\t28\t36.81241623069731\nCough\tUrinary Incontinence, Stress\t99\t130.1581859585369\nCough\tUrinary Incontinence, Urge\t1\t1.3147291510963324\nCough\tFemale Urogenital Diseases\t1\t1.3147291510963324\nCough\tFallopian Tube Diseases\t1\t1.3147291510963324\nCough\tAnovulation\t1\t1.3147291510963324\nCough\tOvarian Hyperstimulation Syndrome\t1\t1.3147291510963324\nCough\tEndometriosis\t4\t5.2589166043853295\nCough\tInfertility, Female\t1\t1.3147291510963324\nCough\tUterine Cervical Incompetence\t1\t1.3147291510963324\nCough\tUterine Prolapse\t4\t5.2589166043853295\nCough\tVaginal Diseases\t2\t2.6294583021926647\nCough\tPregnancy Complications\t5\t6.573645755481662\nCough\tAbruptio Placentae\t1\t1.3147291510963324\nCough\tFetal Membranes, Premature Rupture\t1\t1.3147291510963324\nCough\tPregnancy Complications, Cardiovascular\t1\t1.3147291510963324\nCough\tPregnancy in Diabetics\t1\t1.3147291510963324\nCough\tPuerperal Disorders\t3\t3.944187453288997\nCough\tCardiovascular Abnormalities\t2\t2.6294583021926647\nCough\tHeart Defects, Congenital\t1\t1.3147291510963324\nCough\tCoronary Vessel Anomalies\t1\t1.3147291510963324\nCough\tHeart Septal Defects\t1\t1.3147291510963324\nCough\tHeart Septal Defects, Atrial\t11\t14.462020662059656\nCough\tHeart Septal Defects, Ventricular\t1\t1.3147291510963324\nCough\tTetralogy of Fallot\t1\t1.3147291510963324\nCough\tTransposition of Great Vessels\t1\t1.3147291510963324\nCough\tVascular Malformations\t1\t1.3147291510963324\nCough\tArteriovenous Malformations\t2\t2.6294583021926647\nCough\tVascular Fistula\t1\t1.3147291510963324\nCough\tArterio-Arterial Fistula\t1\t1.3147291510963324\nCough\tHeart Diseases\t11\t14.462020662059656\nCough\tArrhythmias, Cardiac\t15\t19.720937266444984\nCough\tSick Sinus Syndrome\t1\t1.3147291510963324\nCough\tAtrial Fibrillation\t3\t3.944187453288997\nCough\tBradycardia\t1\t1.3147291510963324\nCough\tAtrial Premature Complexes\t3\t3.944187453288997\nCough\tVentricular Premature Complexes\t4\t5.2589166043853295\nCough\tHeart Block\t8\t10.517833208770659\nCough\tAtrioventricular Block\t3\t3.944187453288997\nCough\tLong QT Syndrome\t2\t2.6294583021926647\nCough\tTachycardia\t8\t10.517833208770659\nCough\tTachycardia, Paroxysmal\t1\t1.3147291510963324\nCough\tTachycardia, Supraventricular\t2\t2.6294583021926647\nCough\tTachycardia, Ectopic Atrial\t1\t1.3147291510963324\nCough\tTachycardia, Ventricular\t2\t2.6294583021926647\nCough\tTorsades de Pointes\t1\t1.3147291510963324\nCough\tVentricular Fibrillation\t11\t14.462020662059656\nCough\tCardiac Output, Low\t3\t3.944187453288997\nCough\tCardiac Tamponade\t1\t1.3147291510963324\nCough\tCardiomegaly\t1\t1.3147291510963324\nCough\tHypertrophy, Left Ventricular\t2\t2.6294583021926647\nCough\tHypertrophy, Right Ventricular\t1\t1.3147291510963324\nCough\tCardiomyopathies\t4\t5.2589166043853295\nCough\tCardiomyopathy, Hypertrophic\t2\t2.6294583021926647\nCough\tCardiomyopathy, Restrictive\t1\t1.3147291510963324\nCough\tMyocardial Reperfusion Injury\t1\t1.3147291510963324\nCough\tMyocarditis\t4\t5.2589166043853295\nCough\tHeart Arrest\t11\t14.462020662059656\nCough\tHeart Failure\t31\t40.756603683986306\nCough\tAortic Valve Insufficiency\t2\t2.6294583021926647\nCough\tMitral Valve Prolapse\t1\t1.3147291510963324\nCough\tMitral Valve Insufficiency\t1\t1.3147291510963324\nCough\tMitral Valve Stenosis\t4\t5.2589166043853295\nCough\tTricuspid Valve Stenosis\t1\t1.3147291510963324\nCough\tMyocardial Ischemia\t2\t2.6294583021926647\nCough\tAngina Pectoris\t2\t2.6294583021926647\nCough\tAngina, Unstable\t1\t1.3147291510963324\nCough\tCoronary Disease\t7\t9.203104057674327\nCough\tCoronary Artery Disease\t7\t9.203104057674327\nCough\tMyocardial Infarction\t13\t17.09147896425232\nCough\tShock, Cardiogenic\t2\t2.6294583021926647\nCough\tPericardial Effusion\t3\t3.944187453288997\nCough\tPericarditis\t6\t7.888374906577994\nCough\tPericarditis, Constrictive\t3\t3.944187453288997\nCough\tPneumopericardium\t3\t3.944187453288997\nCough\tPulmonary Heart Disease\t6\t7.888374906577994\nCough\tVentricular Dysfunction, Left\t5\t6.573645755481662\nCough\tTakotsubo Cardiomyopathy\t1\t1.3147291510963324\nCough\tVentricular Outflow Obstruction\t1\t1.3147291510963324\nCough\tVascular Diseases\t2\t2.6294583021926647\nCough\tAneurysm\t5\t6.573645755481662\nCough\tAneurysm, Dissecting\t4\t5.2589166043853295\nCough\tAneurysm, False\t5\t6.573645755481662\nCough\tAneurysm, Ruptured\t2\t2.6294583021926647\nCough\tAortic Rupture\t3\t3.944187453288997\nCough\tAortic Aneurysm\t3\t3.944187453288997\nCough\tAortic Aneurysm, Thoracic\t9\t11.83256235986699\nCough\tAngioedema\t9\t11.83256235986699\nCough\tAortic Diseases\t1\t1.3147291510963324\nCough\tAortitis\t2\t2.6294583021926647\nCough\tArterial Occlusive Diseases\t4\t5.2589166043853295\nCough\tArteriosclerosis\t1\t1.3147291510963324\nCough\tArteritis\t2\t2.6294583021926647\nCough\tDiabetic Angiopathies\t1\t1.3147291510963324\nCough\tDiabetic Foot\t1\t1.3147291510963324\nCough\tEmbolism\t3\t3.944187453288997\nCough\tEmbolism, Air\t13\t17.09147896425232\nCough\tEmbolism, Fat\t1\t1.3147291510963324\nCough\tEmbolism, Paradoxical\t2\t2.6294583021926647\nCough\tVenous Thromboembolism\t1\t1.3147291510963324\nCough\tThrombosis\t3\t3.944187453288997\nCough\tVenous Thrombosis\t1\t1.3147291510963324\nCough\tThrombophlebitis\t3\t3.944187453288997\nCough\tEhlers-Danlos Syndrome\t2\t2.6294583021926647\nCough\tHypertension\t93\t122.26981105195891\nCough\tHypotension\t7\t9.203104057674327\nCough\tSuperior Vena Cava Syndrome\t4\t5.2589166043853295\nCough\tVaricose Veins\t3\t3.944187453288997\nCough\tVasculitis\t3\t3.944187453288997\nCough\tMucocutaneous Lymph Node Syndrome\t7\t9.203104057674327\nCough\tPurpura, Schoenlein-Henoch\t1\t1.3147291510963324\nCough\tChurg-Strauss Syndrome\t3\t3.944187453288997\nCough\tVasculitis, Leukocytoclastic, Cutaneous\t2\t2.6294583021926647\nCough\tVenous Insufficiency\t2\t2.6294583021926647\nCough\tHematologic Diseases\t1\t1.3147291510963324\nCough\tAnemia\t5\t6.573645755481662\nCough\tAnemia, Aplastic\t1\t1.3147291510963324\nCough\tAnemia, Sickle Cell\t13\t17.09147896425232\nCough\tSickle Cell Trait\t1\t1.3147291510963324\nCough\tbeta-Thalassemia\t2\t2.6294583021926647\nCough\tAnemia, Pernicious\t1\t1.3147291510963324\nCough\tAnemia, Refractory\t1\t1.3147291510963324\nCough\tBlood Coagulation Disorders\t1\t1.3147291510963324\nCough\tHemophilia A\t1\t1.3147291510963324\nCough\tWiskott-Aldrich Syndrome\t1\t1.3147291510963324\nCough\tEcchymosis\t2\t2.6294583021926647\nCough\tPurpura\t3\t3.944187453288997\nCough\tThrombocytopenia\t1\t1.3147291510963324\nCough\tAgammaglobulinemia\t2\t2.6294583021926647\nCough\tIgG Deficiency\t1\t1.3147291510963324\nCough\tMyelodysplastic Syndromes\t1\t1.3147291510963324\nCough\tPolycythemia Vera\t3\t3.944187453288997\nCough\tEosinophilia\t48\t63.10699925262395\nCough\tAngiolymphoid Hyperplasia with Eosinophilia\t2\t2.6294583021926647\nCough\tHypereosinophilic Syndrome\t6\t7.888374906577994\nCough\tLeukocytosis\t3\t3.944187453288997\nCough\tLymphocytosis\t2\t2.6294583021926647\nCough\tChediak-Higashi Syndrome\t1\t1.3147291510963324\nCough\tGranulomatous Disease, Chronic\t2\t2.6294583021926647\nCough\tJobs Syndrome         0.000000000
## Mandibular Diseases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           1.000000000

4 Function-based methods

data(d2g_separation) #get disease-gene associations
ds<-sample(names(d2g_separation),5)
ds

## [1] "joint diseases"             "insulin resistance"        
## [3] "connective tissue diseases" "retinal dystrophies"       
## [5] "anemia"

sim<-BOG(ds,ds,d2g_separation)
Normalize(sim) #normalize BOG sim scores

##                            joint diseases insulin resistance
## joint diseases                  0.7899751                  0
## insulin resistance              0.0000000                  1
## connective tissue diseases      0.1174956                  0
## retinal dystrophies             0.0000000                  0
## anemia                          0.0000000                  0
##                            connective tissue diseases retinal dystrophies
## joint diseases                            0.117495563           0.0000000
## insulin resistance                        0.000000000           0.0000000
## connective tissue diseases                0.632504738           0.0000000
## retinal dystrophies                       0.000000000           0.8837116
## anemia                                    0.001490542           0.0000000
##                                 anemia
## joint diseases             0.000000000
## insulin resistance         0.000000000
## connective tissue diseases 0.001490542
## retinal dystrophies        0.000000000
## anemia                     0.928517902

options(stringsAsFactors = FALSE) #this may be neccessary
 
d2g_fundo_sample<-read.table(text = "DOID:5218    IL6
DOID:8649  EGFR
DOID:8649   PTGS2
DOID:8649   VHL
DOID:8649   ERBB2
DOID:8649   PDCD1
DOID:8649   KLRC1
DOID:5214   MPZ
DOID:5214   EGR2
DOID:5210   AMH")

d2g_fundo_list<-x2y_df2list(d2g_fundo_sample)
d2g_fundo_list

## $`DOID:5218`
## [1] "IL6"
## 
## $`DOID:8649`
## [1] "EGFR"  "PTGS2" "VHL"   "ERBB2" "PDCD1" "KLRC1"
## 
## $`DOID:5214`
## [1] "MPZ"  "EGR2"
## 
## $`DOID:5210`
## [1] "AMH"

m<-matrix(1:9,3,3)
m

##      [,1] [,2] [,3]
## [1,]    1    4    7
## [2,]    2    5    8
## [3,]    3    6    9

Normalize(m)

##       [,1]  [,2]  [,3]
## [1,] 0.000 0.375 0.750
## [2,] 0.125 0.500 0.875
## [3,] 0.250 0.625 1.000

## get the data 
data(go2g_sample)
data(d2go_sample)

ds<-names(d2go_sample)
sim<-PSB(ds,ds,d2go_sample,go2g_sample)
sim

##            DOID:5652 DOID:10005  DOID:2290
## DOID:5652  4.1743210 0.44099253 0.51055413
## DOID:10005 0.4409925 5.82708131 0.09897865
## DOID:2290  0.5105541 0.09897865 5.45446576

Normalize(sim)

##             DOID:5652 DOID:10005  DOID:2290
## DOID:5652  0.71146461 0.05970806 0.07185197
## DOID:10005 0.05970806 1.00000000 0.00000000
## DOID:2290  0.07185197 0.00000000 0.93494957

## in this method, we must use disease-gene associations 
## which genes are represented by entrez ids because of
## HumanNet
data(d2g_fundo_entrezid) ##get disease-gene associations
data(HumanNet_sample)
## we specified 5 DOIDs to match Human_sample
ds<-c("DOID:8176","DOID:2394","DOID:3744","DOID:8466","DOID:5679")
llsnlist<-LLSn2List(HumanNet_sample)
FunSim(ds,ds,d2g_fundo_entrezid,llsnlist)

##              DOID:8176  DOID:2394    DOID:3744    DOID:8466 DOID:5679
## DOID:8176 1.0000000000 0.43350044 0.4476822789 0.0002666029 0.1457867
## DOID:2394 0.4335004444 1.00000000 0.4222353572 0.0166884115 0.1592188
## DOID:3744 0.4476822789 0.42223536 1.0000000000 0.0001286379 0.1293250
## DOID:8466 0.0002666029 0.01668841 0.0001286379 1.0000000000 0.1349979
## DOID:5679 0.1457866621 0.15921884 0.1293250308 0.1349979009 1.0000000

## get disease-gene associations and HPRD PPI data
data(d2g_fundo_symbol)
data(PPI_HPRD)

graph_hprd<-graph.data.frame(PPI_HPRD,directed=FALSE) #get a igraph object based on HPRD PPI data

ds<-sample(names(d2g_fundo_symbol),5)
ICod(ds,ds,d2g_fundo_symbol,graph_hprd)

##             DOID:13359  DOID:10130    DOID:630   DOID:2528  DOID:10629
## DOID:13359 1.000000000 0.000000000 0.013605394 0.004129557 0.000000000
## DOID:10130 0.000000000 1.000000000 0.006250387 0.010174617 0.000000000
## DOID:630   0.013605394 0.006250387 1.000000000 0.005786591 0.004238441
## DOID:2528  0.004129557 0.010174617 0.005786591 1.000000000 0.000000000
## DOID:10629 0.000000000 0.000000000 0.004238441 0.000000000 1.000000000

data(d2g_separation) ## get disease-gene associations

ds<-sample(names(d2g_separation),5)
Sun_annotation(ds,ds,d2g_separation)

##                                        mitochondrial diseases
## mitochondrial diseases                             1.00000000
## leukemia, lymphocytic, chronic, b-cell             0.00000000
## lymphatic diseases                                 0.00000000
## intellectual disability                            0.01265823
## central nervous system diseases                    0.05183585
##                                        leukemia, lymphocytic, chronic, b-cell
## mitochondrial diseases                                            0.000000000
## leukemia, lymphocytic, chronic, b-cell                            1.000000000
## lymphatic diseases                                                0.154929577
## intellectual disability                                           0.008196721
## central nervous system diseases                                   0.004464286
##                                        lymphatic diseases
## mitochondrial diseases                        0.000000000
## leukemia, lymphocytic, chronic, b-cell        0.154929577
## lymphatic diseases                            1.000000000
## intellectual disability                       0.004132231
## central nervous system diseases               0.014234875
##                                        intellectual disability
## mitochondrial diseases                             0.012658228
## leukemia, lymphocytic, chronic, b-cell             0.008196721
## lymphatic diseases                                 0.004132231
## intellectual disability                            1.000000000
## central nervous system diseases                    0.017307692
##                                        central nervous system diseases
## mitochondrial diseases                                     0.051835853
## leukemia, lymphocytic, chronic, b-cell                     0.004464286
## lymphatic diseases                                         0.014234875
## intellectual disability                                    0.017307692
## central nervous system diseases                            1.000000000

## get a sample of disease-GO associations
data(d2go_sample)
ds<-names(d2go_sample)
Sun_function(ds,ds,d2go_sample)

##             DOID:5652 DOID:10005  DOID:2290
## DOID:5652  1.00000000          0 0.02672606
## DOID:10005 0.00000000          1 0.00000000
## DOID:2290  0.02672606          0 1.00000000

data(d2g_fundo_symbol)
data(graphlet_sig_hprd) #get graphlet signatures of genes in HPRD PPI network
data(weight)
ds<-sample(names(d2g_fundo_symbol),5)
Sun_topology(ds,ds,d2g_fundo_symbol,graphlet_sig_hprd,weight)

##            DOID:8580 DOID:10530 DOID:2141 DOID:3005  DOID:769
## DOID:8580  1.0000000  0.3762668 0.3971859 0.4465814 0.4455113
## DOID:10530 0.3762668  1.0000000 0.4078183 0.4120618 0.4619584
## DOID:2141  0.3971859  0.4078183 1.0000000 0.3790711 0.5000000
## DOID:3005  0.4465814  0.4120618 0.3790711 1.0000000 0.5000000
## DOID:769   0.4455113  0.4619584 0.5000000 0.5000000 1.0000000

## get the disease-gene association data and interactome data
data(d2g_separation)
data(interactome)

## import ppi data to R by igraph
graph_interactome<-graph.data.frame(interactome,directed=FALSE)

## calculate separation of 5 sample diseases
ds<-sample(names(d2g_separation),5)
sep<-Separation(ds,ds,d2g_separation,graph_interactome)

## convert separation into simialrity
sim<-Separation2Similarity(sep)
sim

##                              arrhythmias, cardiac urogenital neoplasms
## arrhythmias, cardiac                   0.98758776           0.05742388
## urogenital neoplasms                   0.05742388           0.88305820
## respiratory hypersensitivity           0.09025555           0.14995582
## body weight                            0.09618215           0.03241419
## cardiomyopathy, dilated                0.16559761           0.07113121
##                              respiratory hypersensitivity body weight
## arrhythmias, cardiac                           0.09025555 0.096182154
## urogenital neoplasms                           0.14995582 0.032414186
## respiratory hypersensitivity                   1.00000000 0.000000000
## body weight                                    0.00000000 0.971356361
## cardiomyopathy, dilated                        0.04397615 0.006761813
##                              cardiomyopathy, dilated
## arrhythmias, cardiac                     0.165597614
## urogenital neoplasms                     0.071131207
## respiratory hypersensitivity             0.043976151
## body weight                              0.006761813
## cardiomyopathy, dilated                  0.833076722

5 Visualization

data(d2g_fundo_symbol)
d2g_sample<-d2g_fundo_symbol[1:10]
plot_bipartite(d2g_sample)

data("PPI_HPRD")
g<-graph.data.frame(PPI_HPRD,directed = FALSE) #get an igraph graph

data(d2g_fundo_symbol)
a<-d2g_fundo_symbol[["DOID:8242"]] # get gene set a
b<-d2g_fundo_symbol[["DOID:4914"]] # get gene set b

plot_topo(a,b,g)

data(d2g_separation)
data(interactome)

graph_interactome<-graph.data.frame(interactome,directed=FALSE)
ds<-c("myocardial ischemia","myocardial infarction","coronary artery disease",
 "cerebrovascular disorders","arthritis, rheumatoid","diabetes mellitus, type 1",
 "autoimmune diseases of the nervous system","demyelinating autoimmune diseases, cns",
 "respiratory hypersensitivity","asthma","retinitis pigmentosa",
 "retinal degeneration","macular degeneration")
 
sep<-Separation(ds,ds,d2g_separation,graph_interactome)
sim<-Separation2Similarity(sep)
plot_heatmap(sim,font.size = 3)

plot_net(sim,cutoff=0.2)

6 References

[1] Zhou X Z, Menche J, Barabasi A L, et al. Human symptoms-disease network[J]. Nature communications, 2014, 5.

[2] Van Driel M A, Bruggeman J, Vriend G, et al. A text-mining analysis of the human phenome[J]. European journal of human genetics, 2006, 14(5): 535-542.

[3] Cheng L, Li J, Ju P, et al. SemFunSim: a new method for measuring disease similarity by integrating semantic and gene functional association[J]. PloS one, 2014, 9(6): e99415.

[4] Mathur S, Dinakarpandian D. Automated ontological gene annotation for computing disease similarity[J]. AMIA Summits on Translational Science Proceedings, 2010, 2010: 12.

[5] Mathur S, Dinakarpandian D. Finding disease similarity based on implicit semantic similarity[J]. Journal of biomedical informatics, 2012, 45(2): 363-371.

[6] Lee I, Blom U M, Wang P I, et al. Prioritizing candidate disease genes by network-based boosting of genome-wide association data[J]. Genome research, 2011, 21(7): 1109-1121.

[7] Paik H, Heo HS, Ban H, et al. Unraveling human protein interaction networks underlying co-occurrences of diseases and pathological conditions[J]. Journal of translational medicine, 2014, 12(1): 99.

[8] Sun K, Gonçalves JP, Larminie C. Predicting disease associations via biological network analysis[J]. BMC bioinformatics, 2014, 15(1): 304.

[9] Hočevar T, Demšar J. A combinatorial approach to graphlet counting[J]. Bioinformatics, 2014, 30(4): 559-565.

[10] Menche J, Sharma A, Kitsak M, et al. Uncovering disease-disease relationships through the incomplete interactome[J]. Science, 2015, 347(6224): 1257601.

[11] Yu G, Wang L G, Yan G R, et al. DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis[J]. Bioinformatics, 2015, 31(4): 608-609.