scBFA

A dimensionality reduction tool using gene detection pattern to mitigate noisy expression profile of scRNA-seq

Bioconductor version: 3.24 · Package version: 1.27.0

This package is designed to model gene detection pattern of scRNA-seq through a binary factor analysis model. This model allows user to pass into a cell level covariate matrix X and gene level covariate matrix Q to account for nuisance variance(e.g batch effect), and it will output a low dimensional embedding matrix for downstream analysis.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("scBFA")