CONCERTDR

Drug Response Data Analysis Using CMap Database

Bioconductor version: 3.24 · Package version: 0.99.2

Provides a complete pipeline for drug repurposing analysis using the Connectivity Map (CMap) L1000 database. Functionality includes database subsetting, reference profile extraction from GCTX files, signature matching via Kolmogorov-Smirnov, GSEA-based, cosine similarity, and other methods, result annotation against CMap compound metadata, z-score matrix extraction, and publication-quality clustermap visualization via ComplexHeatmap. Connectivity scoring methods (KS, GSEA, XCos, XSum, Zhang) are implemented internally based on the algorithms described in Lamb et al. (2006), Subramanian et al. (2005), Cheng et al. (2014), and Zhang & Gant (2008), removing the need for external GitHub-only dependencies.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("CONCERTDR")