Package: sSeq
Type: Package
Title: Shrinkage estimation of dispersion in Negative Binomial models
        for RNA-seq experiments with small sample size
Version: 1.49.0
Date: 2013-04-17
Author: Danni Yu <dyu@purdue.edu>, Wolfgang Huber <whuber@embl.de> and
        Olga Vitek <ovitek@purdue.edu>
Maintainer: Danni Yu <dyu@purdue.edu>
Depends: R (>= 3.0), caTools, RColorBrewer
Description: The purpose of this package is to discover the genes that
        are differentially expressed between two conditions in RNA-seq
        experiments. Gene expression is measured in counts of
        transcripts and modeled with the Negative Binomial (NB)
        distribution using a shrinkage approach for dispersion
        estimation. The method of moment (MM) estimates for dispersion
        are shrunk towards an estimated target, which minimizes the
        average squared difference between the shrinkage estimates and
        the initial estimates. The exact per-gene probability under the
        NB model is calculated, and used to test the hypothesis that
        the expected expression of a gene in two conditions identically
        follow a NB distribution.
License: GPL (>= 3)
LazyLoad: yes
biocViews: ImmunoOncology, RNASeq
Repository: https://bioc.r-universe.dev
Date/Publication: 2025-10-29 14:14:50 UTC
RemoteUrl: https://github.com/bioc/sSeq
RemoteRef: HEAD
RemoteSha: 0e7ac26e87f19016d92bd682668ba176fafd8d4c
NeedsCompilation: no
Packaged: 2026-02-21 07:18:10 UTC; root
Built: R 4.6.0; ; 2026-02-21 07:19:42 UTC; unix
