BulkSignalR 0.99.0  (First release: 2022-03-22)
==============================================


* This is the first release of BulkSignalR.


BulkSignalR 0.99.0  (2024-09-17)
==============================================


* Code redesign : Major update to add the derived classes enabling the comparisons of groups of samples

############################################
#  Version 2 : LRDBv1 + Upgrade Reactome   #
############################################
3820 Interactions :
836 Genes annotated as Ligand only.
727 Genes annotated as Receptor only.

39 genes are defined both as ligand and receptor in 332 interactions.

############################
#  Version 1 : LRDBv1      # 
############################
3239 Interactions :
786 Genes annotated as Ligand only.
730 Genes annotated as Receptor only.

20 genes are defined both as ligand and receptor in 109 interactions.
 "ADAM17"  "CD36"    "CD48"    "CD80"    "EFNA3"   "NECTIN3" "PLG"    
 "PVR"     "TYROBP"  "ITGB2"   "HLA-F"   "CEACAM1" "PECAM1"  "CD22"   
 "NECTIN1" "CEACAM8" "CD1D"    "CD177"   "CLEC2B"  "CD47"   

Some interactions were found to be duplicated and duplicates were removed.
CCL17    ACKR1
CCL2    ACKR1
CCL5    ACKR1
CCL7    ACKR1
CXCL1    ACKR1
CXCL5    ACKR1
INHBE   ACVR2B
INHBE   ACVR2B
INHBE   ACVR2B
SEMA4A   PLXND1
PVR     CD96
INHBE   ACVR2B

Spotted some inversions in description for SEMA4A PLXNB1 interaction.
Also ACVR2B was found with different descriptions whereas gene name occurs several times.
So Description for each gene was rewritten once according to biomart. 

Change according to multichecker (https://www.genenames.org/tools/multi-symbol-checker/)
Note HLAE was changed to HLA-E.
Note BY55 was changed to CD160.
Note MTf was changed to MELTF.
Note SHP1 was changed to PTPN6.
Note SHP2 was changed to PTPN11.
Note TIM-1 was changed to HAVCR1.
Ambiguous (failed with multichecker):
Note NOV was changed to CCN3 according to (hugo,omnipath,celltalk)
