tnsCoxInteraction,TNS-method {RTNsurvival} | R Documentation |
Cox regression analysis for dual regulons, including the interaction term.
## S4 method for signature 'TNS' tnsCoxInteraction(tns, stepFilter = TRUE, pValueCutoff = 0.05, verbose = TRUE)
tns |
A TNS object with regulons used to compute the dual regulons. |
stepFilter |
A single logical value specifying to use a step-filter algorithm, testing dual regulons that have at least one significant predictor in the 'tnsCox' method (when stepFilter=TRUE) or not (when stepFilter=FALSE). |
pValueCutoff |
An numeric value. The p-value cutoff applied to the results from the previous steps of the analysis pipeline (when stepFilter=TRUE). |
verbose |
A logical value specifying to display detailed messages (when verbose=TRUE) or not (when verbose=FALSE). |
Cox hazard models and statistics.
An updated TNS-class object containing Cox regression models for all given duals
# load survival data data(survival.data) # load TNI-object data(stni, package = "RTN") # perform survival analysis for regulons stns <- tni2tnsPreprocess(stni, survivalData = survival.data, time = 1, event = 2) stns <- tnsGSEA2(stns) # run Cox regression for dual regulons stns <- tnsCoxInteraction(stns, stepFilter = FALSE) tnsGet(stns, "coxInteractionTable")