HSA {synergyfinder}R Documentation

Calculate HSA synergy score

Description

HSA calculates the synergy score matrix for a block of drug combination by using Highest Single Agent (HSA) reference model.

Usage

HSA(response.mat)

Arguments

response.mat

A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.

Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The reference effect of drug combination is the maximal single drug effect".

Value

A matrix for synergy score calculated via Highest Single Agent (HSA).

Author(s)

References

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
HSA.score <- HSA(data$dose.response.mats[[1]])

[Package synergyfinder version 2.2.4 Index]