Bliss {synergyfinder}R Documentation

Calculate Bliss synergy score

Description

Bliss calculates the synergy score matrix for a block of drug combination by using a druginteraction reference model introduced by C. I. Bliss in 1939.

Usage

Bliss(response.mat)

Arguments

response.mat

A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.

Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The expected effect of two drugs acting independently".

Value

A matrix for synergy score calculated via reference model introduced by C. I. Bliss.

Author(s)

References

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
Bliss.score <- Bliss(data$dose.response.mats[[1]])

[Package synergyfinder version 2.2.4 Index]