identifymiRTargetsByEnsemble {miRLAB}R Documentation

Identify the top miRNA targets by an ensemble method with ICP-PAM50, Pearson and Lasso

Description

This function identifies the top miRNA targets by an ensemble method with ICP-PAM50, Pearson and Lasso.

Usage

identifymiRTargetsByEnsemble(d, nmiR, nmR, fiftymRNAsData, top = 1,
  topk = 500)

Arguments

d

A matrix of expression of miRNAs and mRNAs with columns being miRNA or mRNA names and rows being samples

nmiR

Number of miRNAs

nmR

Number of mRNAs

fiftymRNAsData

A matrix of expression of 50 mRNAs in PAM50 with columns being mRNA names and rows being samples

top

1 if getting the top of all miRNAs and 2 if getting the top of each miRNA

topk

Number of the top to get

Value

The top k miRNA targets

References

1. Parker, J. S., et al. (2009). "Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes." Journal of Clinical Oncology 27(8): 1160-1167.


[Package miRLAB version 1.18.0 Index]