sim.intervention {nem} | R Documentation |
Simulates a knock-down of a list of network nodes and returns the network nodes and effect reporters, where effects are expected.
sim.intervention(x, int, T=1)
x |
nem object |
int |
a character vector of nodes in the network |
T |
number of time steps to be simulated (only for dynoNEMs) |
list with two slots:
Sgenes.effected |
effected network nodes (by intervention) |
Egenes.effected |
most likely effected downstream effect reporters (by intervention) |
Egenes.effected.prob |
probability of each reporter to be effected by the respective intervention experiment. |
Holger Froehlich
data("BoutrosRNAi2002") D <- BoutrosRNAiDiscrete[,9:16] res = nem(D, control=set.default.parameters(unique(colnames(D)), para=c(0.13,0.05))) sim.intervention(res, "rel") # simulate knock-down of rel