birta-package {birta} | R Documentation |
Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and post-transcriptional degradation by microRNAs. birta uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and Markov-Chain-Monte-Carlo is applied to sample the activity states.
Package: | birta |
Type: | Package |
Version: | 0.99.1 |
Date: | 2012-03-6 |
License: | GNU GENERAL PUBLIC LICENSE (GPL) >= 2 |
LazyLoad: | yes |
Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Frohlich Maintainer: Benedikt Zacher <zacher@lmb.uni-muenchen.de>
B. Zacher, K. Abnaof, S. Gade, E. Younesi, A. Tresch, and H. Frohlich. Joint Bayesian Inference of Condition Specific miRNA and Transcription Factor Activities from Combined Gene and microRNA Expression Data. submitted, 2012.