ppi_enrichment {STRINGdb} | R Documentation |
Computes the enrichment in protein-protein interactions.
ppi_enrichment(hitList, ppi_network)
hitList |
sorted list of proteins (from the most significant to the least significant) |
ppi_network |
an igraph object containing the graph of the protein-protein interaction's network. |
enrichment |
pvalue that describes the probability to get such a number of interactions by chance |
lambda |
expected number of interactions |
Andrea Franceschini
Pradines JR, Farutin V, Rowley S, Dancik V. Analyzing protein lists with large networks: edge-count probabilities in random graphs with given expected degrees. J. Comput. Biol. 2005;12:113-128. Franceschini, A et al. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. In:Nucleic Acids Res. 2013 Jan;41(Database issue)